What drugs should not be taken with CBD?

The cannabis plant has hundreds of chemicals and more than 100 cannabinoids. CBD s the second most abundant chemical compound of the cannabis plant. But CBD has a number of health and therapeutic benefits. But the question arises of how CBD interacts with different medicines. We are going to learn everything about it in this article.

CBD interaction with drugs and medications:

A number of medicines are advised not to take with citrus fruit. A number of medicines are broken down in the liver and small intestine by a group of proteins called cytochrome P450 enzymes (CYPs).

A study, “Grapefruit Medication Interactions: Forbidden Fruit or Avoidable Consequences?” was published in the Canadian Medical Association journal in 2013, which showed that grapefruit is to increase blood content levels when they interact with 85 different drugs. Irregular heartbeat, organ failure, internal bleeding, and death are the consequences.

Let’s examine the current research on CBD’s interaction with several common prescription and over-the-counter medications. 

Should I take CBD with Tylenol?

The generic name of Tylenol is acetaminophen. This is a common drug that is used to relieve pain and fever. The disadvantage of this drug is that it carries the hazard to damage the liver. It also has side effects of nausea, headaches and insomnia. Both CBD and Tylenol are metabolized by CYP450 which are responsible to lower the effectiveness of both chemicals as they get into the body.

A study back in 2019 found that a high dose of CBD can damage the liver. But much more research is needed to support this narrative. It would be best for the people who want to take both CBD and Tylenol simultaneously, to consult their doctors first.

Can CBD be taken with Metoprolol?

Metoprolol is used to control high blood pressure. It helps reducing the heart rate and changes the release of a hormone called epinephrine which causes stress. But this drug has side effects like nausea, stomach ache, heartburn, dizziness and cod hands and feet.

No specific research has done on the ability of CBD to lower high blood pressure but a study was conducted back in 2017 at university of Nottingham UK, that study got published in the journal JCI Insight. This study claimed that CBD helps reducing high blood pressure.

It would be the best for the people who wants to take both CBD and Metoprolol simultaneously, to consult their doctors first.

Should I take CBD with Metformin?

Adults use Metformin to control blood sugar level. This drug comes with the side effects like low blood sugar, nausea, diarrhea, vomiting and muscle pain.

A study was published in the journal Autoimmunity back in 2006 which showed that CBD is helpful in reducing diabetes in animals’ models. But mush more research is needed to support this narrative.

It would be the best for the people who wants to take both CBD and Metformin simultaneously, to consult their doctors first.

Should I take CBD with Xanax?

The generic name of Xanax is alprazolam. This drug is sed to treat panic disorder, anxiety and depression. This drug comes with side effects like drowsiness, lack of coordination, memory loss and anxiety in early morning.

Xanax breaks down in the liver via an enzyme called CYP3A4, which is inhibited by CBD. Taking CBD could potentially increase the amount of time Xanax is in the system and prolong or increase the likelihood of unwanted side effects. CBD may one day be considered an alternative to Xanax as various research, including a 2011 study published in the journal Neuropsychopharmacology, has documented the cannabinoid’s potential anti-anxiety properties.

It would be the best for the people who wants to take both CBD and Xanax simultaneously, to consult their doctors first.

Should I take CBD with statins?

Statins are used to lower cholesterol and saves you from heart attack and stroke. Few of the side effects of statins are muscle soreness, blood sugar increase, headaches, and nausea. 

No particular research has conducted to know the interactions between CBD and statins. It would be the best for the people who wants to take both CBD and statins simultaneously, to consult their doctors first.

Drugs that should not be taken with CBD:

These drug that should not be taken with CBD includes benzodiazepines, antihistamines, haloperidol, antiretrovirals, statins, cyclosporine, sildenafil, warfarin, and other drugs metabolized by CYP3A4 and CYP2D6. Clobazam which is used to treat epileptic seizures should not also be used with CBD.

Does CBD oil affect blood pressure?

A study, “A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study” was published in the journal JCI Insight back in 2017. This study supported the ability of CBD to lower high blood pressure. Because CBD has anti-anxiety and anti-stress properties, so CBD can be helpful in lowering high blood pressure.

Does CBD oil thin the blood?

No study supports the narrative that CBD oil thins the blood. But one thing is certain that CBD oil increases the effects of blood thinning drugs like warfarin.

Does caffeine counteract CBD?

The mixture of caffeine and CBD is getting popular day by day. Caffeine can keep sleep-deprived individuals alert and clear-headed. Further, a 2007 study on rats published in the journal Pharmacology Reports showed that caffeine is metabolized by CYP enzymes, which CBD inhibits. This could extend the time caffeine stays in the body and has the potential to extend the stimulating effects of caffeine.

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