The difference between CBG vs. CBD

The difference between CBG vs CBD, Our knowledge about cannabinoids Increases with every passing day. CBD and THC enjoy the spotlight for a long time, but now a chemical compound called CBG is highlighted.

A number of studies have examined that CBD and CBG both share so many characteristics, they both are non-intoxicating and both are helpful in boasting antioxidative, neuroprotective, and analgesic properties. If you use both of them against inflammation, they do wonders.

What is CBG:

The difference between CBG vs CBD, Cannabigerol is also known as CBG. Cannabis has more than 120 cannabinoids, and cannabigerol is one of them. It was isolated in 1964 for the first time. Many studies suggest that CBG also has many therapeutic properties to benefit us.  CBG’s analgesic properties may surpass those of THC without the intoxicating hit. There’s also evidence to suggest CBG may offer anticancer, antidepressant, and antibacterial qualities.

What is CBD?

The difference between CBG vs. CBD. Cannabidiol is known as CBD. This is a cannabinoid found in high concentrations in types 2 and 3. We can get CBD from both cannabis and hemp as well. The era of the 1930s when CBD isolated from cannabis for the first time.

It was the era of the 1970s when researchers started taking an interest in it. Scientists slowly started exploring both the health and therapeutic properties of CBD. The thing about CBD, it has anti-inflammatory, analgesic, anti-anxiety, anti-nausea, and sedative qualities.

The difference between CBG vs CBD. CBD has stolen the spotlight in recent years because of its therapeutic properties. CBD interacts with the endocannabinoid systems of our body which is responsible to keep balance in our body.

Difference between CBG and CBD:

There are a number of critical ways in which CBD is different from CBG:

• Molecular structure:

Cannabigerol and cannabidiol have different molecular structures. Molecular structure refers to the number and arrangement of hydrogen, carbon, and oxygen atoms that constitute a cannabinoid. Dissimilar molecular structures mean that CBD and CBG have different three-dimensional shapes, and therefore bind with the body’s cannabinoid receptors in different ways and act on the body distinctively. A cannabinoid’s molecular structure also helps determine the bioavailability of the cannabinoid, and its degree of solubility in water.

• Pharmacology: 

CBD and CBG also activate receptors differently. For example, a 2011 study published in Psychopharmacology compared the effects of CBD and CBG at the 5-HT1A serotonin receptor. CBD appears to exert its anti-nausea effects through its affinity for the 5-HT1A receptor, acting as an agonist (activator). CBG, on the other hand, behaves as an antagonist (blocker) at the 5-HT1A receptor. The findings showed that a pre-treatment with CBG blocked CBD’s anti-emetic effects, suggesting that the two cannabinoids bound to the same place, but had opposing actions at this receptor.

• Appetite stimulation: 

Another critical way in which CBG differs from CBD is in appetite stimulation. Research in rats showed that doses of CBG encouraged the animals to eat more than double their normal food intake. In another study, cannabigerol didn’t induce any changes to feeding behavior, but cannabidiol significantly reduced total food intake.

Therapeutic effects of CBG:

No clinical trials have conducted on humans yet to understand the effects of CBG. Few of the studies have examined the therapeutic effects of CBG. CBG is also a non-intoxicating chemical compound.

• Appetite stimulation: 

As already discussed, preclinical studies have revealed that CBG can markedly promote appetite in rats. A 2017 study emphasized the therapeutic significance of this finding, pointing out that purified CBG may represent a novel treatment option for cachexia, appetite loss, and wasting in humans. Unlike THC, CBG can help to drive hunger without any undesirable intoxicating effects.

• MRSA bacterial infections:

CBG has also demonstrated its clout as a potent antibiotic. Researchers tested the antibacterial potential of 18 different cannabinoids, including cannabigerol, against MRSA. CBG outperformed all of the cannabinoids tested and worked as well as vancomycin, a powerful antibiotic.

• Cancer: 

CBG boasts anti-cancer properties due to its ability to inhibit abnormal cell proliferation. Research has provided evidence of its anti-tumorigenic properties by inhibiting the formation of mouse skin melanoma cells.

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