CBD and Diarrhea

CBD oil has a number of medical and therapeutic properties. Basically, that is why CBD oil is getting popular among not only doctors but also patients who are trusting it. Just like any other drug, CBD oil has its own side effects. However, they are limited as compared to over the counter medicines and especially pharmaceutical drugs.

Do CBD oil cause diarrhea? We are going to learn all about it in this article.

Research overview:

Mayo Clinic reporting back in 2019 that CBD is generally well-tolerated but may cause a number of side effects — among them, diarrhea. Few studies have shown the result that there is a certain link between CBD oil and diarrhea. But much more research is needed to support this narrative.

The studies:

Can CBD oil help diarrhea?

CBD oil may trigger diarrhea and a number of other inflammatory bowel disease symptoms. A literature review was published in the journal Gastroenterology and Hepatology back in 2016. According to this literature review, both cannabis and CBD can treat IBD therapeutically. The author says, “A significant portion of IBD patients, particularly those with severe disease. Generally, they use cannabis to relieve symptoms of pain, nausea, and appetite. Also improving their overall mood.”

Results of a study wrote in the scientific journal Inflammatory Bowel Diseases in 2018 determines that “CBD-rich botanical extracts may beneficial in treating symptomatic ulcerative colitis.”

Can CBD oil causes diarrhea?

A report in the journal Current Neuropharmacology wrote in 2019, which discusses the effects of CBD based on clinical trials of the FDA-approved drug Epidiolex. prescribing it to treat childhood epilepsy. The researchers were of the view that diarrhea is one of the side effects of CBD.

Patients perspectives:

Brooke Bogdan is addressing his symptoms of ulcerative colitis by using medical cannabis since 2012. An article on Everyday Health in 2019, in which Bogdan shares her experience of using medical cannabis for relief from chronic pain. She was in need to have a surgical procedure to remove the colon before she started using cannabis.

She experienced improvements as long as she started taking cannabis. Bogdan wrote, “Cannabis helped provide an outlet of relief for me when I was close to losing my life. When prescription medication doesn’t help my ulcerative colitis symptoms, I turn to cannabis.”

Perspectives of CBD:

Bogdan specifically mentioned vape pens, dabs, and tinctures were of great help as far as relief from pain is concerned. But she wanted people from using edibles to cope with ulcerative colitis because “Our digestive tracts don’t function well. Therefore, we may not be able to absorb the medication into our systems via chewing and swallowing.”

Curt Rollins worked with his hands to design intricate floral arrangements for baby showers and weddings for 30 years. “I loved the work, but my hands paid the price,” Rollins revealed in a phone interview with Weedmaps.

His both hand developed debilitating arthritis, and he started taking painkillers and cortisol shots, but he did not get any relief. His doctor advised him to start taking CBD oil, and he started seeing improvements. “The pain got a lot better without too many side effects. But I did find that my stomach would get a bit upset if I had too much CBD oil every day,” Rollins shared.

500 milligrams or more is considered to be a high dose of CBD. Rollins continued, “When I reduced the dose or just rubbed the CBD oil on my hands instead of swallowing it too, I didn’t have any problems with nausea or diarrhea anymore.”

Opinion of experts:

According to Dr Adie Rae, a neuroscientist at Legacy Research Institute in Portland, Oregon, and a scientific adviser to Weedmaps. “Yes, CBD causes diarrhea at high oral doses, as reported in the Epidiolex clinical trials and randomized clinical trials in adults,” said Rae.

Rae was quick to add that “most people will not take enough CBD to cause diarrhea; this usually happens at very high doses of 500 milligrams or more.”

Some individuals may experience diarrhea after taking 400 milligrams of CBD oil. Both height and weight of the consumer play a vital part in this regard. Other important factors like dietary habits, exercise frequency, and general health also play their role in determining if the person is going to have diarrhea or not.

Rae noted that there is little evidence that CBD is a directly useful tool. She asserted, however, that “CBD could still improve the quality of life for patients suffering from chronic bowel disorders, even if it doesn’t improve some specific symptoms like diarrhea.”


A strong dose of CBD oil may trigger mild to moderate diarrhea, but if you take a lower dose of CBD, no study has found any such side effects of CBD oil. Much more study is needed in this regard.

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